DDW geographic point.

In another concentration presented during this year’s DDW geographic point, Wani and colleagues evaluated 699 consecutive patients to delineate features that may be predictive of erosive esophagitis or NERD. Thirty-five percent of their universe had erosive esophagitis diagnosed on pep pill endoscopy. Compared with patients with NERD, patients with erosive esophagitis were younger, more likely to be smokers and nonusers of PPIs, and more likely to have more severe and frequent GERD symptoms. Patients with erosive esophagitis were also more likely to have nocturnal symptoms and a hiatal hernia. When subjected to a logistic fixation depth psychology to adjust for potential difference confounders, the relation between erosive esophagitis and hiatal hernia and nocturnal symptoms remained stable, as did the relation between age and use of PPIs in patients with NERD.
Last year, in our brushup of GERD that was based on data presented during DDW 2005, we discussed new acid growing agents, such as the potassium-competitive acid blockers. These highly lipophilic, weak bases accumulate within the parietal cell at much greater concentrations (> 1000x) than PPIs and act by reversibly blocking potassium debut into the parietal cell, resulting in rapid rises in gastric pH after ingestion. These medications appear to have a more rapid military operation of physical process and greater dominance than the currently available delayed-release PPIs. The results of a dose-ranging absorption of one of these agents, Azd0865, was reported by Kahrilas and colleagues during this year’s social affair. In this domain, 1521 patients with erosive esophagitis were randomized to receive Azd0865 in 1 of 3 doses (25, 50, or 75 mg/day) or discount nexium 40 mg/day. Endoscopic healing was assessed at 2, 4, and 8 weeks, with healing at 4 weeks defined as the pinion endpoint.
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