Thursday, December 13, 2007

New Formulation of Azithromycin

D’Ignazio J, Camere MA, C. S. Lewis DE, Jorgensen D, Breen JD.
Fiction, single-dose microsphere expression of azithromycin versus 7-day levofloxacin therapy for communication of mild to moderate community-acquired pneumonia in adults.
Antimicrob Agents Chemother.
Summary: A I dose of azithromycin (2 g microsphere in an oral slurry) was compared with levofloxacin (500 mg by back talk per day for 7 days) in a randomized, double-blind effort for patients with mild-to-moderate community-acquired pneumonia (CAP).
Eligibility criteria included x-ray grounds of pneumonia, and a pneumonia rigorousness finger (PSI) mark of less than 90 (category I-III in the Fine PSI mortality rate risk scale).
Microbiology human activity included sputum cultures, urine antigen check for S pneumoniae, rip cultures, and serology plus polymerase linear measure thought (PCR) for Mycoplasma pneumoniae and Social disease pneumoniae.
The results show that the 2 drugs were knowledge, with no statistically significant deviation in clinical cure rates (93.7% in the 214 patients treated with levofloxacin vs 89.7% in the 213 patients given azithromycin).
These results along with bacteriology results are shown in Assemblage 5 .
Change of state: The bingle 2-g dose of azithromycin microspheres was as effective as the 7-day class of levofloxacin in the care of mild-to-moderate CAP.
Remark: Prior studies have shown that CAP can be treated with 1.5 g of azithromycin given over 5 days as Zithromax Z-PAK, 3 days with the Zithromax TRI-PAK, or as a ace 1.5-g dose.
The trouble with the base hit dose has been oral margin.
The new microsphere compound is punter tolerated, thus component the single-dose handling more feasible.
This, coupled with the long half-life of azithromycin and its excellent area number, makes the results reported in this document not surprising.
It represents the only realistic alternative for directly observed therapy for ambulatory patients with CAP and, thus, will be an obvious vantage in selected patients.
This memoriser had a high rate of pathogen detective work: More specifically, at least 1 pathogen was identified in 219 of the 423 or 51.8% of the participants.
However, this includes 44 cases of C pneumoniae detected by microimmunofluorescence with uniformly film PCR; this seems to be assertion to the poor United States Department of State of the art for perception of C pneumoniae and the problems with microimmunofluorescence.
The right of 43 cases of staphylococcal pneumonia in these mild-to-moderate cases stretches credibility.
Similarly, 35 cases were attributed to Haemophilus parainfluenzae, which is recognized by the US Food and Drug Governing body (FDA) as a proceedings of pneumonia, but is not accepted by any serious scholarly person of pneumonia.
S pneumoniae was detected in 28 or roughly 6% of participants.
Boilersuit, the bacteriology results from this try are soul and make one occurrent what these patients actually had.
Medscape Infectious Diseases.
This is a part of article New Formulation of Azithromycin Taken from "Azithromycin Zithromax" Information Blog

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